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6 Future research directions and challenges 6.1 Mechanistic exploration: deciphering dual roles and context-specific signaling The dual immunomodulatory effects of microbial metabolitessuch as butyrate enhancing CD8 + T cell cytotoxicity while suppressing DC functionand their receptor-specific mechanisms (e.g., SCFAs via GPR41/43, Trp derivatives via AhR/IDO1) demand systematic resolution

Biomonitoring of the mycotoxin Zearalenone: current state-of-the art and application to human exposure assessment

Finally, further studies should clarify the molecular pathways involved and extend the one-time application (much like the engraftment of neural stem cells [16] or bone marrow stromal cells [17] into the lesion site) to the continuous application for the recovery of pre-existing spinal cord injury

doi: 10.3390/nu11030616

Biomaterials 278 , 120433 (2021)

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